Job title: Principal Scientist
Dr. Reto Horst is a Principal Scientist in the Structural and Molecular Sciences group at Pfizer in Groton, CT. He is developing and applying cutting edge NMR methods to identify and validate hits from various screening funnels and to characterize protein–ligand interactions. Dr. Horst has guided fragment-based drug discovery efforts in various disease areas and made key contributions to several discovery projects. Dr. Horst obtained a diploma (MSc) in Physics and a PhD in Biophysics under the supervision of Nobel Laureate Dr. Kurt Wuthrich at the ETH in Zurich, Switzerland. Before joining Pfizer in 2012, he was a Staff Scientist at Scripps Research in La Jolla, CA, where his research was focused on studying GPCR signalling pathways and chaperonin-assisted protein folding by solution state NMR spectroscopy, resulting in more than 30 peer-reviewed publications that appeared in Tier 1 journals including Cell, Science and PNAS.
Discussion/Q&A 10:00 am
day: Day Two
Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy 9:20 am
The receptor tyrosine kinase (RTK) TrkA is a target for the treatment of severe and chronic pain Due to the high structural similarity between TrkA and other RTKs, eliminating undesirable side effects and designing more selective inhibitors remains a challenge We targeted TrkA dynamics by use of protein NMR in combination with other structural biology…Read more
day: Day Two