Company: Silicon Therapeutics
Job title: Director of Biophysics & Biochemistry
Dr. Holly Soutter is Director of Biophysics and Biochemistry at Silicon Therapeutics leading a group responsible for protein generation, structural biology, biophysics, assay development and validation. She has 15 years of experience in the pharmaceutical and biotech sectors. Before joining Silicon Therapeutics, she led a group at X-Chem Pharmaceuticals supporting DEL screening and was a Principal Scientist at Pfizer providing structure-based drug design support for projects in multiple therapeutic areas including in oncology, anti-infectives, immunology, cardiovascular and inflammation. She is co-inventor of multiple clinical candidates, co-author of 22 peer-reviewed publications and a named inventor on two patents.
Drugging the Undruggable: Integration of Biophysics, Genetics, Molecular Dynamics and Docking 11:30 am
What to do in the absence of a crystal structure: constrained docking using HDX and STD-NMR in concert with Med. Chem. SAR for progressing chemical matter Integrated chemistry/simulation/biophysics/assay strategy for the development of STING agonists orthogonal computational tools and biophysical techniques which span different timescales, functional forms, and experimental modalities impacting molecular design and the…Read more
day: Day Two